The legendary John Ford directs this provocative and acclaimed film based on the Pulitzer Prize-winning novel by Sinclair Lewis and adapted by Sydney Howard.

Country doctor Martin Arrowsmith (Ronald Colman) is idealistic, hardworking and happily married to Leora (Helen Hayes). He's also about to make a terrible mistake. Lured away from his small practice by the prospect of wealth and important medical research, he takes a position with New York City's esteemed McGurk Institute. It's a big opportunity - but it brings bigger problems. The intense workload, a romance-minded socialite (Myrna Loy) and a terrible plague outbreak are about to threaten everything Martin holds dear.