Distress is a comedy about a trio of beautiful girls as they set out to revolutionize life at a grungy American university the dynamic leader Violet Wister (Greta Gerwig), principled Rose (Megalyn Echikunwoke) and sexy Heather (Carrie MacLemore). They welcome transfer student Lily (Analeigh Tipton) into their group which seeks to help severely depressed students with a program of good hygiene and musical dance numbers. The girls become romantically entangled with a series of menincluding smooth Charlie (Adam Brody), dreamboat Xavier (Hugo Becker) and the mad frat pack of Frank (Ryan Metcalf) and Thor (Billy Magnussen) who threaten the girls friendship and sanity.