In this suspenseful sequel to In the Heat of the Night, Academy Award winner Sidney Poitier reprises his role as the intrepid investigator who, this time, must solve a puzzling murder in the City by the Bay. Featuring an original score by Quincy Jones and co-starring Oscar winner Martin Landau and Edward Asner (JFK), They Call Me Mister Tibbs! is "an absorbing mystery that ranks as one of the best" (Boxoffice).

When a prostitute is murdered in San Francisco's ritzy Nob Hill district, an anonymous tip implicates minister and political crusader Reverend Logan Sharpe (Landau). Lt. Virgil Tibbs (Poitier), who has known Sharpe for many years, asks to be assigned to the case in hopes of clearing his friend's name. So begins the detective's journey through a twisted maze of baffling evidence, frantic chases, deadly gunfire and bad alibis. Before long, Tibbs finds himself bitterly torn between his duty as a cop…and his loyalty to a friend.