"A Boy and His Dog" tells the story of Vic (Don Johnson) and his telepathic dog, Blood (Tim McIntire, voice). The movie is set in the year 2024, and Vic and Blood find themselves living in the post-nuclear wasteland that has become America. Vic and Blood spend most of their time looking for their two most desired and therefore important needs food and sex. With the help of the highly intelligent and witty Blood, Vic is able to find a lot of both. Vic is then lured by Quilla (Susanne Benton) into an odd underground world, where he will be used as a fertile young male to impregnate the young women in the twisted society. When he figures out that this underground world is not what he wanted after all, Vic has to try to find a way to escape and reunite with Blood.