Resident Evil: Degeneration begins shortly after the events of the Resident Evil 4 game. The Umbrella Corporation is dissolved following a series of catastrophes centering on its research of biological weapons and viruses. After escaping the disaster at Raccoon city seven years previous, we are reintroduced to survivor Claire Redfield (Alyson Court). Now a member of human rights organization TerraSave, we find her waiting at the Harvardville airport amidst the controversy surrounding new Pharmaceutical company WilPharma. While waiting she finds herself caught in a incident with a man who viciously attacks an airport security guard, only to reanimate and attack another after being pronounced dead. She fast realizes that the episode is really the beginnings of another biohazard outbreak. Meanwhile Leon S. Kennedy (Paul Mercier), another survivor of the Raccoon city disaster and now a U. S. special agent, is sent in to the airport to rescue Senator Ron Davis (Micheal Sorich). While on his mission he is reunited with Claire and the two join forces to escape, discovering a deeper conspiracy at the core of the incident. Join Claire and Leon as they struggle to unravel the mystery surrounding this airport disaster, the Senator's appearance in Harvardville, WilPharma's and their new research laboratory all the while trying to deal with Umbrella's legacy while trying to prevent another catastrophe!