Four college guys, Josh (Breckin Meyer), E. L. (Sean William Scott), Rubin (Paulo Costanzo) and Kyle (DJ Qualls), who are heading down to Austin, TX from Ithaka, NY. The reason for this long road trip is a “dirty” video tape that was mistakenly sent to Josh’s longtime girlfriend, Tiffany. Josh and his friends are trying to prevent Tiffany from seeing the tape. Along the way, the guys run into issues, which cost them valuable time. Meanwhile, back in Ithaka, Beth (Amy Smart), the girl who hooked up with Josh, decides to follow Josh in order to find his girlfriend. However, due to misinformation, Beth is heading to Boston, Massachusetts.