In this completely animated feature, where the actors are voices only, the little mouse Stuart Little (Michael J. Fox) joins his adopted human family at a lakeside vacation and tries to join the Lake Scouts with his people brother George Little (Corey Padnos). This brings expected misadventures when mouse and human interactions are problematic, but there is a bigger problem, a scary creature who lurks in the woods, The Beast (Virginia Madsen). This Beast terrorizes all the forest animals, and Stuart and his friends become new targets. Stuart teams up with his cat Snowbell (Nathan Lane) and a new buddy, Reeko the skunk (Wayne Brady), to deal with the monster. Reeko is a bit of a smart alec, but proves to be a brave and true friend when Snowbell is snatched by The Beast, and the friends work together to try to overcome the evil creature.