Stuart Little, Mouse Extraordinary, has fully settled in with his human family in this sequel. He evens has a red sportscar! Then one day, Stuart (Micheal J. Fox) saves a damsel in distress. The damsel is a canary named Margalo (Melanie Griffith) who was being threatened by a Falcon (James Woods). After the rescue, Stuart is happy to have a new friend, especially one more his own size. But soon Margalo disappears and Stuart is afraid she has been bird-napped by the Evil Falcon. While his brother George(Jonathan Lipnicki) covers for him at home, Stuart sets off across the city with the cat Snowbell (Nathan Lane) in tow. He must find Margalo.