Dr. Anton Phibes (Vincent Price) returns to life three years after his previous series of murders, intent upon using a set of scrolls left in his house to find the Pharoah's Tomb in Egypt, where the River of Life flows and he can try to revive his deceased wife. Be he finds that his home has been demolished and the scrolls taken, so he packs his equipment and with his assistant Vulnavia (Valli Kemp) is soon of the trail of Darius Biederbeck (Robert Quarry), who is using the scrolls to find the River of Life for himself.