Jigsaw has vanished and now with his new apprentice, Amanda by his side he plays perhaps his last vicious game. While the police scour the area trying to find him, a doctor is captured by Amanda and taken to a warehouse where she meets the notorious Jigsaw. On the brink of death and bedridden, the doctor is told she must keep him alive for as long as possible, in order to complete a final game involving one of his victims Jeff. Lynn and Jeff are forced to play a dangerous game, not knowing that Jigsaw and Amanda have one more card left to play.