Nemo Nobody (Jared Leto) is a regular, everyday man, living with his wife Elise (Sarah Polley) and their 3 children. His life is nothing special, though it is happy. One day, everything gets turned upside down - somehow, he wakes up in the year 2092, and old man aged 120. He's not sure how he got there or what all he missed along the way, but Nemo quickly learns that he is the last mortal on the planet - people in this new world no longer die. Rather than concerning himself with this new and different reality, Nemo sets out to discover how he lived his life, and whether he had led a happy and successful life.