Ham the Third (Andy Samburg) is the grandson of Ham, the first chimpanzee to ever venture in to space. However, Ham III is not at all like his grandfather and is undisciplined and fun-loving. In fact, he works as a circus chimp who gets fired out of cannons. But when a billion dollar satellite gets lost in a wormhole, NASA decides to send three chimpanzees to investigate. The aforementioned Ham III, Luna (Cheryl Hines) and Captain Titan (Patrick Warburton). As they go trough the wormhole, they find a strange world with its inhabitants being ruled by an evil dictator called Zartog who plans to use the probe to cause destruction. They make friends with one of the inhabitants and try to save the planet from Zartog and to get back home.