An abortion clinic counselor Miriam Toll (Lisa Kudrow) harbors a secret from when she was younger. Together with her gay stepbrother Charlie (Steve Coogan) they produced a son who was given up for adoption. Miriam or Mamie as she is known is in a relationship with Javier (Bobby Cannavale) who also happens to be a massage therapist. A film maker shows up and plans to blackmail her with information on her child's whereabouts. Meanwhile, her gay brother Charlie suspects that his boyfriend may have given sperm to a lesbian couple Pam (Laura Dern) and Diane (Sarah Clarke) to help them have a daughter.