A disturbed couple, known as He (Willem Dafoe) and She (Charlotte Gainsbourg), mourn the death of their small child, but their grief quickly descends into nightmares and surreal living conditions. They seem to have a sexual liaison that in some way was responsible for the death of an innocent child. He and She go to a deserted cabin called Eden to work out their kinks, but whatever they see or do, they are catapulted into deeper madness and melancholia. He is not helped by the fact he is an academic, studying the abuse of women who are labeled witches. They come to realize their world is inhabited by a pure incarnate evil ready to spill out again in bizarre and violent examples of mutilation and sexual humiliation.