Leo (Gael García Bernal) and Ellen (Michelle Williams) are man and wife, settled in New York. They are fully absorbed in their job. Leo is a website designer and has a flourishing business, while his wife Ellen is a devoted surgeon, destined to save lives. Their young daughter Jackie (Sophie Nyweide), who is only eight years old, is always with her Filipino nanny Gloria (Marife Necesito). This makes Ellen think of prioritizing her areas. Leo takes a trip to Thailand on business, while he inadvertently causes a series of incidents that result in someunexpected and serious consequences.