A group of anthropology students, led by professor Dr. Michael Hauser, (Joe Jones) are summoned to investigate a series of unsolved mysterious murders at the legendary island prison, Alcatraz where their remains are discovered in a sealed room. However, unknown to them within the walls of the prison an unsuspecting and unimaginable harrowing event is about to happen when one of them, Ranger Vince (William van Noland) accidentally cuts his hand on one of the well preserved mummified corpse of a Native American. It then unleash a terrible curse in which a virus turns hapless infected people into bloodthirsty maniacs. They must now battle one another in order to get out of the island alive.