When young Kate (Sofia Vassilieva) was born with a rare form of leukemia and no donor matches within their immediate family, parents Sara (Cameron Diaz) and Brian Fitzgerald (Jason Patric) decide to use scientific advances to impregnate Sara with a child who will be a donor match for Kate. Anna (Abigail Breslin) is born out of this scientific advancement, and she is often unable to lead a normal life due to her responsibilities to be a donor for Kate whenever she relapses and needs a new procedure. Anna has donated everything from blood to bone marrow to her sister. When Kate goes into renal failure and it appears that Anna will be asked (or forced) to donate a kidney to her sick sister, Anna sues her parents for medical emancipation. After some convincing, Campbell Alexander (Alec Baldwin) agrees to take her case on, pro bono. Will Anna be able to go through with the case, and ultimately win the medical emancipation that may well result in killing Kate, or will she have a change of heart?