When four ordinary citizens respond to an advertisement for a paid research study they are soon surprised to find that they are part of a closed room psychological experiment. The group soon learn that they are being manipulated as part of a government military experiment, controlled and anticipated by some of the best minds of the CIA. As Dr. Phillips (Peter Stormare) uses more and more unethical behaviors to direct the experiment to achieve his desired results, Dr. Reilly (Chloe Sevigny) wonders how it will all end.