Detective Aidan Breslin (Dennis Quaid) uncovers a string of gory, gristly, exacting murders that all seem to have something in common. The killings seem to be based on biblical prophecies surrounding the four horsemen of the apocalypse: War, Famine, Pestilence, and Death. Recently widowed, Breslin finds the horror of the case is pulling him away from his remaining family, his sons Alex (Lou Taylor Pucci) and Sean (Liam James). A soft-spoken Chinese woman, Kristen (Ziyi Zhang), just may be the key to uncovering the killings.