A detective named Danny Fisher (John Cena) discovers that his loving girlfriend named Molly Porter (Ashley Scott) has been kidnapped by internationally known terrorist Miles Jackson (Aidan Gillen), who is nearly untraceable. The terrorist forced him into "12 Rounds" of dangerous games which were carefully plotted throughout the streets of New Orleans. Danny Fisher struggles and tries his best to save his girlfriend to keep while the obvious ticking clocks and crude consequences which accompany each one of these "rounds" do their best to derail him from rescuing the love of his life before it's too late.