Harry and Kate Mackenzie married for better or worse and after 30 years, their union is neither better nor worse. Instead, it somehow simply died. But Harry has a second chance in life. He's met a woman who rekindles his sense of life's fullness. But Harry knows taking that chance will cause his family pain.

As directed by Bud Yorkin, from a screenplay by Chariots of Fire Oscar®-winner Colin Welland, a sharply attuned cast depicts how divorce impacts a family. Gene Hackman (Harry), Ellen Burstyn (Kate) and Ann-Margret portray the focal triangle. Ally Sheedy and Amy Madigan play daughters with opposite perspectives on their father's decision. Filmed in and around Seattle, Twice in a Lifetime takes an optimistic outlook: out of change and hard realities can come new beginnings and new hopes for each family member.